|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
PRACTICAL APPLICATIONS: Mfn2 and Drp1, as the main regulators of the mitochondrial fusion and fission, play an important role in maintaining mitochondrial dynamics and type 2 diabetes.
|
31849103 |
2020 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer.
|
31838085 |
2020 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer.
|
31838085 |
2020 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The findings of this study suggest that Drp1-regulated PARK2-dependent mitophagy plays a critical role in hypoxia-induced renal tubular epithelial cell injury and renal fibrosis in UUO.
|
31825802 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Drp1 was significantly overexpressed in lung cancer tissues based on Oncomine and TCGA databases (P < .05).
|
31770286 |
2019 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Drp1 was significantly overexpressed in lung cancer tissues based on Oncomine and TCGA databases (P < .05).
|
31770286 |
2019 |
|
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Drp1 was significantly overexpressed in lung cancer tissues based on Oncomine and TCGA databases (P < .05).
|
31770286 |
2019 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alterations of genes encoding Sirt1, Mfn1 and Drp1 in an experimental model of AD suggest that modulation of mitochondria dynamics and Sirt1, including miRNA strategy, may be crucial for improvement of AD therapy.
|
31734880 |
2020 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic investigations revealed that increased DRP1 upregulation-mediated mitochondrial fission and subsequently enhanced aerobic glycolysis was involved in the promotion of growth and metastasis by DRP1 in PC cells.
|
31674061 |
2019 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We first found that DRP1 was substantially upregulated in PC cell lines and tissue samples mainly due to the downregulation of miR-29a, which contributed to the poor survival of PC patients.
|
31674061 |
2019 |
|
Malignant neoplasm of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We first found that DRP1 was substantially upregulated in PC cell lines and tissue samples mainly due to the downregulation of miR-29a, which contributed to the poor survival of PC patients.
|
31674061 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer.
|
31639424 |
2020 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer.
|
31639424 |
2020 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
SIK2 promotes reprogramming of glucose metabolism through PI3K/AKT/HIF-1α pathway and Drp1-mediated mitochondrial fission in ovarian cancer.
|
31639424 |
2020 |
|
Parkinson Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
Drp-1 inhibition mediated neuroprotective effects in PD rats were associated with increased level of protein kinase-B/Akt and extracellular-signal-regulated kinase (ERK).
|
31626851 |
2020 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, the number of fragmented mitochondria and Drp1(Ser<sup>616</sup>) phosphorylation were trended to reduce/reduced (0.0104, 95% CI [0.0085, 0.0126], P = 0.091 and 0.0085, 95% CI [0.0068, 0.0102], P = 0.05) in myotubes derived from severely obese humans at 7 months after RYGB surgery in comparison with the presurgery state.
|
31624314 |
2020 |
|
Parkinson Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease.
|
31578315 |
2019 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
|
31412251 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.030 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drp1 by Mdivi-1 treatment or si-Drp1 transfection increased CDDP sensitivity of ovarian cancer cells under hypoxia.
|
31409904 |
2019 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drp1 by Mdivi-1 treatment or si-Drp1 transfection increased CDDP sensitivity of ovarian cancer cells under hypoxia.
|
31409904 |
2019 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of Drp1 by Mdivi-1 treatment or si-Drp1 transfection increased CDDP sensitivity of ovarian cancer cells under hypoxia.
|
31409904 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis.
|
31377418 |
2019 |
|
Fuchs Endothelial Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunoblotting of FECD ex vivo specimens revealed an accumulation of PINK1 and phospho-Parkin (Ser65) along with loss of total Parkin and total Drp1.
|
31361992 |
2019 |
|
Diabetic Nephropathy
|
0.030 |
Biomarker
|
disease |
BEFREE |
The AKAP1-Drp1 pathway may contribute to mitochondrial fission in the pathogenesis of DN.
|
31349216 |
2019 |
|
Hypertensive disease
|
0.030 |
Biomarker
|
group |
BEFREE |
Our study suggests that calcineurin/Drp1-dependent mitochondrial fission may be essential for understanding adventitial remodeling in hypertension and that HSP90 inhibition may serve as a novel approach for the treatment of adventitial remodeling-related diseases.
|
31346611 |
2020 |